Molecular Mechanisms in the Function of Neurotransmitter Transporters: Multi-scale Computational Studies  on Membrane Proteins - Sebastian Stolzenberg - Bøker - LAP LAMBERT Academic Publishing - 9783659562921 - 27. juni 2014
Ved uoverensstemmelse mellom cover og tittel gjelder tittel

Molecular Mechanisms in the Function of Neurotransmitter Transporters: Multi-scale Computational Studies on Membrane Proteins

Sebastian Stolzenberg

Pris
zł 198,90

Bestillingsvarer

Forventes levert 22. apr - 2. mai
Legg til iMusic ønskeliste

Molecular Mechanisms in the Function of Neurotransmitter Transporters: Multi-scale Computational Studies on Membrane Proteins

In my Ph. D. research work, I investigate functional mechanisms of complex molecular machines in the cell membrane that carry out the transport (reuptake) of neurotransmitter molecules into the cell. I apply and develop methods of computational biophysics to reveal and quantify the molecular transport process that is essential for the ability of the cell to continue to signal. Such detailed understanding is highly significant because dysfunction of these transporter proteins is known to be involved in neurodegenerative diseases, depression, epilepsy and stroke. The molecular mechanistic insights gained on multiple scales from my research work pertain to (1) a major conformational transition in the substrate translocation mechanism of Glutamate Transporters, and (2) allosteric changes in the substrate transport mechanism of the Neurotransmitter: Sodium Symporter proteins. The computational approaches that enabled these mechanistic insights include Motion Planning, mixed Elastic Network Models, (targeted) Molecular Dynamics Simulations, Free Energy Perturbations, and various statistical analysis methods.

Media Bøker     Pocketbok   (Bok med mykt omslag og limt rygg)
Utgitt 27. juni 2014
ISBN13 9783659562921
Utgivere LAP LAMBERT Academic Publishing
Antall sider 168
Mål 152 × 229 × 10 mm   ·   254 g
Språk Engelsk