Partition Equilibrium and Lipophilicity of Hydroxamic Acids

N-Arylhydroxamic acids are drug like molecules. Biological activity always depends upon physico-chemical property namely lipophilicity, which has direct impact on the potency of the molecule. Partition coefficient is a measure of how well a substance partitions between a lipid and water. The partition coefficient has a strong influence on ADME properties of molecules. Both of these parameters are important factor in QSAR.