Cardioprotective Effect of Combination of Enalapril and Fenofibrate: a Hemodynamic, Biochemical and Histopathological Study

Doxorubicin (Adriamycin) is a well known anticancer drug used to cause cardiac damage in rats. In this book, combination of Enalapril and fenofibrate were assessed for cardioprotective effect. Parameters evaluated were ECG, blood pressure, serum markers viz. LDH, CK-MB, SGPT, SGOT, ALP, serum urea and serum creatinine. Tissue antioxidant markers viz. CAT and SOD, lipid peroxidation (MDA) for heart, liver and kidney and histopathological study of heart, liver and kidney. Parameters such as body weight, organ weight (heart, liver and kidney) and organ/body weight ratio were also evaluated.